OLIGO-ARN DOUBLE HÉLICE SPÉCIFIQUE DE L'AMPHIRÉGULINE, STRUCTURE EN DOUBLE HÉLICE D'OLIGO-ARN COMPRENANT LEDIT OLIGO-ARN DOUBLE HÉLICE ET COMPOSITION DESTINÉE À PRÉVENIR OU TRAITER LES MALADIES RESPIRATOIRES EN CONTENANT
The present invention relates to an amphiregulin-specific double-stranded oligo siRNA, which can inhibit the expression of amphiregulin with high efficiency and can be effectively used for the prevention or treatment of respiratory diseases. Moreover, the present invention relates to an amphiregulin-specific double-stranded oligo siRNA structure that comprises hydrophilic and hydrophobic compounds bound to the amphiregulin-specific double-stranded oligo siRNA by a simple covalent bond or a linker-mediated covalent bond so as to increase the in vivo stability and intracellular delivery efficiency of the double-stranded oligo siRNA, and to nanoparticles composed of the oligo siRNA structures. The amphiregulin-specific double-stranded oligo siRNA structure according to the present invention can increase the stability of the amphiregulin-specific double-stranded oligo siRNA without impairing the function of the amphiregulin-specific double-stranded oligo siRNA, and at the same time, can efficiently increase the membrane permeability of the double-stranded oligo siRNA. Thus, when the amphiregulin-specific double-stranded oligo siRNA structure is used, the amphiregulin-specific double-stranded oligo siRNA can be efficiently delivered into cells even when it is administered at a relatively low concentration, so that it can be effectively used for the prevention or treatment of respiratory diseases.
