MARTINEZ BOTELLA, Gabriel,SALITURO , Francesco G.,ROBICHAUD, Albert Jean,HARRISON , Boyd L.
申请号：
CO2018000589
公开号：
CO2018000589A2
申请日:
2018.01.22
申请国别(地区):
CO
年份:
2018
代理人:
摘要：
The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.Se proporcionan compuestos de acuerdo a la Fórmula (I): (I) y sales farmacéuticamente aceptables de los mismos, y composiciones farmacéuticas de los mismos； en donde R1, R2, y R5 son como se definen en la presente. Los compuestos de la presente invención se consideran útiles para la prevención y tratamiento de una variedad de afecciones.
