A system for endoscopic nuclear imaging, a nuclear probe and related methods are provided. In one embodiment, a system includes a movable endoscopic nuclear probe which comprises a collimator and a detector, the endoscopic nuclear probe having an elongated body with a longitudinal axis (X), wherein the detector and the collimator are arranged on the elongated body, and the collimator having a field of view with an axis (Y) and the axis (Y) is angled with respect to the axis (X) of the elongated body of the endoscopic nuclear probe means for determining the position and orientation of the elongated body of the endoscopic nuclear probe an evaluation unit including means for computationally determining an actual position and actual orientation of the elongated body of the endoscopic nuclear probe and a program storage section and means for computing at least one quality parameter of the image.
