Danilenko Lyudmila Mikhajlovna,Pokrovskij Mikhail Vladimirovich,Kotelnikova Alla Sergeevna,Pokrovskaya Tatyana Grigorevna,Peresypkina Anna Aleksandrovna,Beskhmelnitsina Evgeniya Aleksandrovna,Yakushev Vladimir Ivanovich,Kostina Darya Aleksandrovna,Skachilova Sofiya Yakovlevna,Shilova Elena Vladimirovna,Burda Yurij Evgenevich
申请号：
RU20170139785
公开号：
RU2669348(C1)
申请日:
2017.11.15
申请国别(地区):
俄罗斯
年份:
2018
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention relates to medicine, in particular to experimental pharmacology. Method is proposed for inhibiting the nuclear factor kappa B in a cell culture comprising adding a bacterial lipopolysaccharide at a concentration of 1 mcg/ml to a freshly isolated standard ficoll density gradient test for mononuclear blood cells of Wistar rats, characterized in that 2-ethyl-6-methyl-3-hydroxypyridinium L-2,6-diaminohexanoate is then added to this mixture at a final concentration of 35 mcg/ml.EFFECT: technical result consists in the expressed inhibition of the nuclear factor kappa B in the cell culture and in the favorable safety profile.1 cl, 1 tbl
