LAMONT, GILLIAN MGREGOR,FALLAN, CHARLENE,NISSINK, JOHANNES WILHELMUS MARIA,RASMUSSON, TIMOTHY GORDON,HAYHOW, THOMAS GEORGE CHRISTOPHER,KETTLE, JASON GRANT,YANG, BIN
申请号：
ARP180103831
公开号：
AR114168A1
申请日:
2018.12.21
申请国别(地区):
AR
年份:
2020
代理人:
摘要：
Illustrative memory generally refers to formula compound (1),And your products and drugs are acceptable, where R1,R830808，R83099，R8310，R8311th，Cans, x, y, a, G, D and E have any of the meanings defined in this document. The illustrative report also mentions the use of these compounds and pharmaceutically acceptable salts and solutions in the treatment of humans or animals, such as in the prevention or treatment of cancer. The illustrative report also covers the intermediate processes and compounds related to the preparation of these compounds and the pharmaceutical components containing them. 1. Claim 1: a formula compound (1),O salts or pharmaceutically acceptable salts, where R1 stands for H or methyl； a and G are independent of Cr or N； R 2 is independent of H, F, Cl, CN, methyl or methodxi； D and E are independent of Cr or N； R3 is independent of H, F, CL or methyl； r83088 is for H, methyl or F； R 2 is independent of H, F, CN, methyl or methodxi； D and E are independent of Cr or N； R3 is independent of H, F, CL or methyl； r83088 is for H, methyl or F； R830909 represents h, methyl or F； or r830808 and r83099 form a ring of cycloacrylonitrile or oxyethane with the carbon atoms attached to them； r8310 represents h, methyl, F, ch8322；； F, chf832222；CF8323，Cn, ch8322；； CN, ch83222；； me, ch8322；； Oh, C (o) Oh, C (o) ome o so83222；； me； r8311representative h, methyl-ch8322；； nhme, ch8322；； nme8322222；X stands for... O-Ch=CH-C（O）NH-，-NHC（O）..-c（o）NH-O-Pirrolidinil-Nmec（o）-；E represents an O-C (o) link；Can is an alternative alternative combination, consisting of four to six carbon atoms consisting of a four to twenty carbon atom beam splitting or non splitting, ring or non ring junction, saturated or unsaturated chain, in which 1 to 6 carbon atoms can be replaced by a heteromorphic atom independent of O, N and s.La memoria descriptiva se refiere en general a compuestos de fórmula (1), y sales y profármacos farmacéuticamente aceptables de los mismos, donde R¹, R⁴, R⁵, R⁶,
