Ústav Organické Chemie A Biochemie Akademie Ved Ceské Republiky, v.v.i.;Fyziologický Ústav Akademie VÊD Ceské Republiky V.V.I.;Národní ústav dusevního zdraví
发明人:
申请号：
EP16001932.9
公开号：
EP3243829A1
申请日:
2010.05.28
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The presented invention applies to the compounds with general formula I, where R1 stands for a group of the general formula R3 OOC-R2- C (R4)-R5 -, where R2 stands for alkyl or alkenyl group with 1 to 18 carbon in a straight or a branching carbon chain, which may be substituted by one or more halogen atoms； R3represents either a hydrogen atom or a protecting group of carboxyl groups, preferably benzyl group； R4 represents oxygen atom, nitrogen atom or a sulfur atom bound by a double bond or R4 represents two hydrogen atoms； R5 represents any at least bivalent atom, preferably an oxygen atom, nitrogen, or carbon atom, except when R2 represents the group -(CH2)n- where n = 0-3 and simultaneously R3 represents a hydrogen atom and R4 and R5 represent an oxygen atom. The present invention also relates to the production process of the compounds with general formula I, where R1 stands for as mentioned previously, the compounds with general formula I for use in treatment of various diseases of central nervous system, in treatment of neuropsychiatric disorders related to imbalance of glutamatergic neurotransmitter system, ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, PTSD and other diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain, addictions, multiple sclerosis, epilepsy and gliomas.This invention further applies to the compounds with general formula I for use in the production of veterinary and human pharmaceutical preparations for use in treatment of above mentioned diseases as well as in production of substances used in experimental research, analytic chemistry, dietary supplements or cosmetic preparations.
