STEFAN DR. SCHUNK,MELANIE DR. REICH,FLORIAN DR. JAKOB,NILS DR. DAMANN,MICHAEL DR. HAURAND,ACHIM DR. KLESS,MARC DR. ROGERS,KATHY DR. SUTTON
申请号：
ARP150101120
公开号：
AR100073A1
申请日:
2015.04.14
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
Voltage activated calcium channel blocker (CAV) and other useful compounds. The pharmaceutical ingredients that contain them Used in the treatment and / or prevention of pain and other diseases and / or diseases. 1. Requirement 1: a compound (1) with common formula characteristics,M stands for 0, 1 or 2； n stands for 0 or 1； and is selected from the y-c (R3) link group；where each R³ is independently selected from the group consisting of H and C₁₋₆-alkyl, or two R³ together with the C atom connecting them a C₃₋₁₀-cycloalkyl or a heterocyclyl of 3 to 7 members ； L is - [C (R⁴) ₂] ˣ- (X) ʸ- [C (R⁴) ₂] ᶻ-,where x is 0, 1 or 2, and is 0 or 1 and z is 0 or 1, with the proviso that x ³ y； each R⁴ is independently selected from the group consisting of H and C₁₋₆-alkyl, or two R⁴ together with the C atom connecting them a C₃₋₁₀-cycloalkyl or a heterocyclyl of 3 to 7 members or two R⁴s together with two adjacent C atoms that connect them with a C₃₋₁₀-cycloalkyl or a heterocyclyl of 3 to 7 members； X is selected from the group consisting of O, S, S (O) ₂,N (H) or N (C₁₋₆-alkyl)；R¹ is selected from the group consisting of H； F； Cl； CN； C₁₋₆-alkyl； C₁₋₆-alkyl-O (R⁵) and C₁₋₆-alkyl-N (R⁵) ₂；where each R⁵ is independently selected from H or C₁₋₆-alkyl or two R⁵ together with the N atom connecting them a heterocyclyl of 3 to 7 members； R² is selected from the group consisting of H； F； Cl； CN； C₁₋₆-alkyl； C₁₋₆-alkyl-O (R⁶) and C₁₋₆-alkyl-N (R⁶) ₂；where each R⁶ is independently selected from H or C₁₋₆-alkyl or two R⁶ together with the N atom connecting them a heterocyclyl of 3 to 7 members； Ar¹ represents aryl or heteroaryl, wherein said aryl or said heteroaryl is substituted with zero or one or two or three substituents R⁷；R8321 is replaced by zero or one or two or three substitutes；a. Each r83111 and r831222 should be selected from group F, Cl, Br and I respectively；Cn； c83218331-832626-tar； cf.83323；CF₂H； CFH₂；CF Cl CFClC (= O) -H； C (= O) -C₁₋₆-alkyl； C (= O) -OH； C (= O) -O-C₁₋₆
