The present disclosure relates to dihydropteridinone derivatives, preparation processes and pharmaceutical compositions containing them. Specifically, the present disclosure relates to novel dihydropteridinone derivatives presented by formula (I), the uses for treatment especially for polo-like kinase protein kinase inhibitors, in which each substitute group of general formula (I) is as defined in the specification.本發明涉及二氫喋啶酮類衍生物、其製備方法及其在醫藥上的應用。具體而言,本發明涉及一種通式(I)所示的新的二氫喋啶酮類衍生物、其製備方法及含有該衍生物的醫藥組成物以及其作為治療劑特別是作為Plk激酶抑制劑的用途,其中通式(I)的各取代基與說明書中的定義相同。