compound, methods for diagnosing fibrosis, and for screening a pharmaceutically active collagen, promoter region of a microrna, and, cell the present invention relates to a promoter region of a microrna, the use of a microrna, in particular mir-21. , and related elements for the diagnosis and manufacture of a medicament for the treatment and / or prevention of fibrosis and / or fibrosis related diseases. furthermore, the invention relates to antilone sense oligonucleotides against mir-21 targets. a mir-21 deficient cell, the mir-21 promoter and target region, and a muted organism thereof are also encompassed. Finally, the invention is directed to a method for diagnosing fibrosis and / or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and / or fibrosis related diseases. The present invention further relates to compositions for use in treating, ameliorating, and / or preventing fibrosis. In certain embodiments, the compositions modulate the activity of a mirna for the treatment, amelioration, and / or prevention of fibrosis. In certain embodiments, the compositions inhibit mir-21 activity for the treatment, amelioration, and / or prevention of fibrosis.composto, métodos para diagnosticar fibrose, e para triar um col 1posto farmaceuticamente ativo, região promotora de um microrna, e, célula a presente invenção diz respeito a uma região promotora de um microrna, o uso de um microrna, em particular mir-21, e elementos relacionados para o diagnóstico e para a fabricação de um medicamento para o tratamento e/ou prevenção de fibrose e/ou doenças relacionadas com a fibrose. adicionalmente, a invenção diz respeito a oligonucleotídeos de antilo sentido contra alvos de mir-21. uma célula deficiente em mir-21, a região promotora e alvos de mir-21 e um organismo silenciado destes também são abrangidos. finalmente, a invenção é direcionada a um método para diagnosticar a fibrose e/ou doenças relacionadas com
