Systems and methods are disclosed for assessing tissue function based on vascular disease. One method includes receiving a patient-specific anatomic model generated from patient-specific imaging of at least a portion of a patients tissue receiving a patient-specific vascular model generated from patient-specific imaging of at least a portion of a patients vasculature receiving an estimate of blood supplied to a portion of the patient-specific anatomic model and determining a characteristic of the function of the patients tissue using the estimate of blood supplied to the portion of the patient-specific anatomic model.
