UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH
发明人:
BRADEN, ARTHUR, R.C.,VISHWANATHA, JAMBOOR, K.
申请号：
EP08745699
公开号：
EP2146694A4
申请日:
2008.04.11
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The present invention includes compositions and methods of making an activated polymeric nanoparticle for targeted drug delivery that includes a biocompatible polymer and an amphiphilic stabilizing agent non-covalently associated with a spacer compound that includes at least one electrophile that selectively reacts with any nucleophilic on a targeting agent and places the targeting agent on the exterior surface of a biodegradable nanoshell, wherein an active agent is loaded with the nanoshell.
