#$%^&*AU2020201403A120200312.pdf#####MICRORNA COMPOUNDS AND METHODS FOR MODULATING MIR-21 ACTIVITY ABSTRACT Described herein are compositions and methods for the inhibition of miR-21 activity. The compositions have certain nucleoside modification patterns that yield potent inhibitors of miR-21 activity. The compositions may be used to inhibit miR-21, and also to treat diseases associated with abnormal expression of miR-21, such as fibrosis and cancer. H12r1JT7AfA