The invention relates to tetrahydroisoquinoline sulfonamide compounds (of formula (1) as defined in the specification), their preparation and their use in therapies for the treatment of central nervous system diseases such as vigilance and sleep disorders, narcolepsy, Alzheimer's disease and other dementias, Parkinson's disease, attention disorders in hyperkinetic children, memory and learning disorders, epilepsy, schizophrenia, moderate cognitive disorders, depression, anxiety, sexual dysfunction, dizziness and travel sickness.本發明係關於對應於式I之化合物：其中：n可採用1至6的值；－(C)n－代表－C1－6亞烷基，其視情況經1至4個取代基取代；R1代表．氫原子，．C1－6烷基；R2代表．氫原子，．C1－6烷基或C3－6環烷基，其中各基團視情況經1至4個取代基取代；B代表．NR3R4，－其中R3及R4彼此獨立代表C1－6烷基或氫原子；或－R3及R4共同代表C1－6亞烷基、C2－8亞烯基、C1－3亞烷基－O－C1－3亞烷基、或C1－3亞烷基－N(R5)－C1－3亞烷基，其中R5代表氫原子或C1－3烷基或C1－6烷基羰基，此等C1－3烷基及C1－6烷基羰基可經取代；或．環胺基，其經由一碳原子鍵結至－NR1－(C)n－基團，該環胺基諸如伸乙亞胺、吖環丁烷、吡咯啶、哌啶或嗎啉；該等R3及R4基團及該環胺基視情況經取代且該氮原子視情況經取代。；本發明係關於該化合物於治療之用途。
