Problem to be solved is to provide a compound or a pharmaceutical composition thereof having excellent syk (Spleen Tyrosine Kinase) inhibitory activity.Solution is to provide a nicotinamide derivative or salt thereof and a pharmaceutical composition for Syk-related disease containing the nicotinamide derivative or salt thereof, wherein the nicotinamide derivative is represented by the formula (I)(In the formula, R1 represents a halogen atom. R2 respectively represents a substituted or unsubstituted C1-12 alkyl, a C2-12 alkenyl, a C2-12 alkynyl, a C3-8 cycloalkyl, an aryl, a arylC1-6 alkyl or a heterocyclic group. R3 represents a substituted or unsubstituted aryl or heterocyclic group.R4 and R5 represents hydrogen atom, ect. R2 and R4 may form a substituted or unsubstituted cycloamine together with nitrogen atom bonding with R2 and R4)本發明之課題在於提供具有優異的Syk抑制活性的化合物及醫藥組成物。一種以通式(I)表示之菸鹼醯胺衍生物或其鹽、及含有前述菸鹼醯胺衍生物或其鹽之Syk相關疾病治療用之醫藥組成物。(式中，R1代表鹵素原子，R2代表也可各具有取代基之C1-12烷基、C2-12烯基、C2-12炔基、C3-8環烷基、芳基、芳基C1-6烷基或雜環基，R3代表也可具有取代基之芳基或雜環基，R4及R5代表氫原子等，R2及R4也可與此等所鍵結之氮原子成為一體而形成也可具有取代基之環狀胺基)。
