AGENTS DE DEGRADATION DE ASH1L ET METHODES DE TRAITEMENT AU MOYEN DE CEUX-CI

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专利权人:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人:

GREMBECKA, JOLANTA,KLOSSOWSKI, SZYMON,DENG, JING,CIERPICKI, TOMASZ,LI, HAO,MIAO, HONGZHI,PUROHIT, TRUPTA,KIM, EUNGI,CHEN, DONG

申请号：

CA3082077

公开号：

CA3082077A1

申请日:

2018.11.09

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

Provided herein are small molecules comprising a first domain that binds to ASH1L and a second domain that facilitates ASH1L degradation. In particular, ASH1L-targeting proteolysis targeting chimeras (PROTACs) and methods of use thereof for the treatment of disease (e.g., acute leukemia, solid cancers and other diseases dependent on activity of ASH1L) are provided.

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中国工程科技知识中心

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http://www.ckcest.cn/home/