JAESCHKE, GEORG,LINDEMANN, LOTHAR,STADLER, HEINZ,VIEIRA, ERIC
申请号：
CA2885382
公开号：
CA2885382A1
申请日:
2013.09.23
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention relates to ethynyl derivatives of formula (I) wherein R is phenyl, 3-fluorophenyl, 4-fluorophenyl or 2,5-di-fluorophenyl； or to a pharmaceutically acceptable acid addition salt, in enantiomerically pure form with the absolute configuration as shown in formula (I). It has now surprisingly been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5) whic are useful for he treatment of schizophrenia, cognitive disorders, fragile X sydrome or autism and which show advantageous biochemical-, physicochemical- and pharmacodynamic- properties compared to compounds of prior art.
