Jaeschke, Georg,Lindemann, Lothar,Stadler, Heinz,Vieira, Eric
申请号：
AU2013329739
公开号：
AU2013329739A1
申请日:
2013.09.23
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The present invention relates to ethynyl derivatives of formula (I) wherein • R is phenyl, 3-fluorophenyl, 4-fluorophenyl or 2,5-di-fluorophenyl； • or to a pharmaceutically acceptable acid addition salt, in enantiomerically pure form with the absolute configuration as shown in formula (I). It has now surprisingly been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5) whic are useful for he treatment of schizophrenia, cognitive disorders, fragile X sydrome or autism and which show advantageous biochemical-, physicochemical- and pharmacodynamic- properties compared to compounds of prior art.
