Yurkovetskiy, Aleksandr,Yin, Mao,Lowinger, Timothy B.,Thomas, Joshua D.,Hammond, Charles E.,Stevenson, Cheri A.,Bodyak, Natalya D.,Conlon, Patrick R.,Gumerov, Dmitry R.
申请号：
AU2016273982
公开号：
AU2016273982A1
申请日:
2016.12.16
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2016273982A120170112.pdf#####001664098_2 ABSTRACT A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by L. Each occurrence of D is independently a therapeutic agent having a molecular weight <；5kDa. LD and IP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymerdrug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
