Aleksandr Yurkovetskiy,Mao Yin,Timothy B. Lowinger,Joshua D. Thomas,Charles E. Hammond,Cheri A. Stevenson,Natalya D. Bodyak,Patrick R. Conlon,Dmitry R. Gumerov
申请号：
US14157154
公开号：
US08821850B2
申请日:
2014.01.16
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a therapeutic agent having a molecular weight ≦5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
