Aleksandr V. YURKOVETSKIY,Mao YIN,Timothy B. LOWINGER,Joshua D. THOMAS,Charles E. HAMMOND,Cheri A. STEVENSON,Natalya D. BODYAK,Patrick R. CONLON,Dmitry R. GUMEROV
申请号：
US15683300
公开号：
US20170348424A1
申请日:
2017.08.22
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a therapeutic agent having a molecular weight ≦5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
