Passerini, Elena,Serraima, Cristina Carreno,Nest, Will Van Den,Montiel, Arturo Puig,Domenech, Nuria Alminana,Puche, Joan Cebrian
申请号：
AU2008243084
公开号：
AU2008243084B2
申请日:
2008.10.31
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2008243084B220120308.pdf#####SYNTHETIC PEPTIDES USEFUL IN THE TREATMENT OF THE SKIN AND USE THEREOF IN COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS ABSTRACT The present invention relates to peptides of general formula (1) capable of regulating fibrillogenesis, stereoisomers thereof and mixtures thereof, which may or may not be racemic, and the cosmetically or dermopharmaceutically acceptable salts thereof, wherein Z is alanyl, allo-isoleucyl, glycyl, isoleucyl, isoseryl, isovalyl, leucyl, norleucyl, norvalyl, prolyl, seryl, threonyl, alo-threonyl or valyl； n and m may vary between 1 and 5； AA is selected from the group consisting of natural amino acids o encoded in their L- or D- form and non-encoded amino acids； x and y may vary between 0 and 2； R1 is H or alkyl, aryl, aralkyl or acyl group； and R2 is amino, hydroxyl or thiol, all of them substituted or non-substituted with aliphatic or cyclic groups. A method for obtaining cosmetic or dermopharmaceutical compositions containing them and use thereof for treating the skin, preferably those skin conditions which require regulating fibrillogenesis, such as aging and/or the softening of the appearance of scars. H2N ( nH 0 H 0 SZ N R2 R(" N z H 0 ()m COOH NH O NH2 (1)
