Steve Andrews,Miles Stuart Congreve,Andrea Bortolato,Jonathan Stephen Mason
申请号：
GB201522431
公开号：
GB2551945A
申请日:
2015.12.18
申请国别(地区):
GB
年份:
2018
代理人:
摘要：
A compound of formula (I): (I) wherein Q is optionally substituted phenyl or monocyclic heteroaryl x is an integer from 1 to 3 R1 & R2 are hydrogen or C1-6 alkyl, or form a ring aa1 is an amino acid G is glycinylT is L-threoninyl aa2 is an amino acid W is L-serinyl or 2,3-diaminopropionyl aa3 is an amino acid aa4 is an amino acid aa5 is a linking group Z is hydrogen, -COOR8 or -CONR9R10 R8, R9 and R10 are hydrogen or C1-6 alkyl or a tautomeric or stereochemically isomeric form or a prodrug, salt or zwitterion thereof. The compounds of formula (I) are Glucagon-like peptide-1 (GLP-1) receptor agonist peptides and are useful in treating diseases or conditions mediated by insulin, such as diabetes mellitus type 1 or 2. The invention further relates to compositions containing said peptides and processes for their preparation.
