CARRENO SERRAÏMA, Cristina,VAN DEN NEST, Wim,SEMPERE BONETE, Ana,FERRER MONTIEL, Antonio,ALMINANA DOMENECH, Nuria,CEBRIAN PUCHE, Juan
申请号：
ES10775716
公开号：
ES2621542T3
申请日:
2010.10.22
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A peptide of general formula (I) R1-Wn-Xm-AA1-AA2-AA3-AA4-Yp-Zq-R2 (I) its stereoisomers, mixtures thereof and / or its cosmetically or pharmaceutically acceptable salts, characterized in that: AA1 is -His-； AA2 is selected from the group consisting of -His-, -Leu- and -Pro-； AA3 is -Leu-； AA4 is selected from the group consisting of -Arg- and-Asn-； W, X, Z and Y are independently selected from the group consisting of the encoded amino acids and the uncoded amino acids； n, m, p and q are independently selected from one another and have a value between 0 and 1； n + m + p + q is less than or equal to 2； R1 is selected from the group consisting of H, substituted noncyclic aliphatic group selected from the group of acetyl, tert-butanoyl, hexanoyl, 2-methylhexanoyl, octanoyl, decanoyl, lauroyl, myristoyl, palmitoyl, stearoyl, oleoyl, and linoleoyl, or a group unsubstituted non-cyclic aliphatic, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, and R5-CO- in which R5 is selected from the group consisting of in H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, unsubstituted aryl, unsubstituted aralkyl, substituted or unsubstituted heterocyclyl, and substituted or unsubstituted heteroarylalkyl； R2 is selected from the group consisting of -NR3R4, -OR3 and -SR3, wherein R3 and R4 are independently selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted heterocyclyl or unsubstituted, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl； with the proviso that when AA2 is -Leu-, AA4 is -Asn-, Y is -Gln- then Z is not -Leu-； and with the proviso that when AA2 is -His-, AA4 is -Arg-, Y or Z are -Tyr- then p + q is not 1.Un pép
