The present invention relates to a controlled release pharmaceutical composition and a preparation method thereof. In particular, the present invention relates to a controlled release pharmaceutical composition comprising a) an active drug-containing core； b) an outer layer comprising at least one matrix-forming agent. By means of the controlled release pharmaceutical composition of the present invention, the residence time of the drug in the stomach can be prolonged, thereby prolonging the transport of the drug throughout the gastrointestinal tract and increasing the absorption of the drug.本發明涉及一種控釋藥物組合物及其製備方法。具體而言，本發明涉及的控釋藥物組合物含有a）含活性藥物的片芯；b）外包層，所述外包層含有至少一種基質形成劑。通過本發明提供的控釋藥物組合物，可以延長藥物在胃內滯留時間，從而延長藥物在整個胃腸道的轉運，增加藥物吸收。
