It regards the controlled release characteristic medicine composition, and that production method of rebechirasetamu with 1 day 1 dosage. Being the controlled release characteristic tablet of rebechirasetamu, it possesses the core which includes rebechirasetamu and the water dispersed speed adjustment polymer, said tablet core water non detachability and/or regards the controlled release characteristic tablet which as needed coating is done with the functional tunic which includes the combination of the water detachable polymer. As for this invention, removing the trough and peak of the medicine density in the blood blood plasma of the patient, while making the occurrence of harmful phenomenon the spiritual nerve decrease, in regard to the persistent remedy which spans 24 hours it offers effective blood plasma level, it features that being oral, it prescribes the controlled release characteristic tablet which approximately offers the peak blood blood plasma level of 8 - approximately 16 hour rebechirasetamu to the patient whose remedy is necessary. The said core is produced with wet granulation, dry granulation or direct making tablet, as needed tablet core is done coating in the coating pan or in the fluidized bed system.1日1回投与でのレベチラセタムの徐放性医薬組成物、およびそれの製造方法に関する。レベチラセタムの徐放性錠剤であって、レベチラセタムおよび水分散速度調節ポリマーを含んだコアを有し、該錠剤コアが水非分散性および/または水分散性ポリマーの組合せを含んだ機能的な被膜で適宜コーティングされている徐放性錠剤に関する。本発明は、患者の血液血漿における薬物濃度のトラフとピークを除去して精神神経に有害な現象の発生を減少させながら、24時間にわたる持続性治療上有効な血漿レベルを提供し、治療が必要な患者に約8~約16時間レベチラセタムのピーク血液血漿レベルを提供する徐放性錠剤を経口で投与することを特徴とする。該コアは湿式造粒、乾式造粒または直打錠で製造され、適宜錠剤コアがコーティングパン中または流動層システム中コーティングされる。
