A work vehicle guidance system includes a control system that has a controller having a processor and a memory. The control system is configured to determine a relative location of a work vehicle to a work area. Moreover, the control system is configured to determine an end-of-row turn path for the work vehicle based at least on the relative location of the work vehicle and a minimum turning radius of the work vehicle. The end-of-row turn path is configured to direct the work vehicle to turn from a first main swath of the work area to a headland swath of the work area, travel along the headland swath in direction toward a second main swath of the work area, and turn from the headland swath to the second main swath. Further, the control system is configured to output a guidance signal comprising guidance instructions to implement the end-of-row turn path.
