to provide a pharmaceutical composition comprising sustained-release lipid initial formulation of anionic pharmacologically active substance and this. present invention, a) a liquid crystal forming agent, b) a phospholipid and (phospholipid), c) a liquid crystal curing agent, d) a divalent or higher valent metal salts, comprise, in the absence of aqueous fluid and present as a lipid liquid phase to provide a sustained-release lipid initial formulation to form a liquid crystal on the aqueous fluid. Slow release lipid initial formulations of the present invention, the action and effect that it is possible to enhance the sustained release of anionic pharmacologically active substances through an ionic bond between the divalent or higher valent metal salt and an anionic pharmacologically active substance It is shown.FIELD 3アニオン性薬理学的活性物質の徐放性脂質初期製剤およびこれを含む薬剤学的組成物を提供すること。本発明は、a)液晶形成剤と、b)リン脂質(phospholipid)と、c)液晶硬化剤と、d)2価以上の金属塩と、を含み、水性流体の不在下で脂質液相として存在し且つ水性流体上で液晶を形成する徐放性脂質初期製剤を提供する。本発明の徐放性脂質初期製剤は、2価以上の金属塩およびアニオン性薬理学的活性物質間のイオン結合を通じてアニオン性薬理学的活性物質の徐放性を強化させることができるという作用効果を示す。【選択図】図3
