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HARCINOL AND CYCLODEXTRIN COMPLEX AND METHOD OF ITS APPLICATION
专利权人:
ИНДЭС БАЙОТЕК ПРАЙВЕТ ЛИМИТЕД (IN)
发明人:
БАСКАРАН Сунил (IN),ВИШВАРАМАН Мохан (IN)
申请号:
RU2013131247/15
公开号:
RU2013131247A
申请日:
2011.01.25
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. The complex of Garcinol and cyclodextrin, in which the molar ratio of Garcinol to cyclodextrin is in the range from about 1: 1 to 1: 4.5.2. The complex according to claim 1, which is a chemical complex. 3. The complex of claim 1, wherein the garcinol has a purity in the range of about 95% to 99%. The complex of claim 1, wherein the cyclodextrin is selected from the group consisting of α-cyclodextrin, β-cyclodextrin, 2-hydroxy-propyl-β-cyclodextrin and their derivatives. The complex of claim 1, wherein the cyclodextrin is β-cyclodextrin. The complex of claim 1, wherein the cyclodextrin is a suitable β-cyclodextrin derivative. A method of obtaining a complex of garcinol and cyclodextrin, in which the molar ratio of garcinol to cyclodextrin is in the range from about 1: 1 to 1: 4.5, which includes a) dissolving the garcinol in a solvent with cyclodextrin to obtain a mixture; b) heating the mixture under reflux with obtaining a clear solution; c) cooling the clear solution to obtain crystals of a complex of garcinol and cyclodextrin; and d) filtering and drying the crystals to obtain a complex of garcinol and cyclodextrin having a molar ratio of garcinol to cyclodextrin of about 1: 1 to 1: 4.5, respectively. The method of claim 7, wherein the solvent is selected from the group consisting of water, aliphatic alcohols with carbon atoms ranging from 1 to 4, and any combination thereof. The method of claim 7, wherein the cyclodextrin is selected from the group consisting of α-cyclodextrin, β-cyclodextrin, 2-hydroxy-propyl-β-cyclodextrin and their derivatives. The method of claim 7, wherein the cooling of the clear solution takes place�1. Комплекс гарцинола и циклодекстрина, в котором молярное соотношение гарцинола к циклодекстрину находится в пределах примерно от 1:1 до 1:4.5.2. Комплекс по п. 1, который представляет собой химический комплекс.3. Комплекс по п. 1, в котором гарцинол имеет чистоту в пределах примерно от 95% до 99%.4. Комплекс по п. 1, в котором циклодекстр
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