PROCESS FOR PRODUCING OPTICALLY ACTIVE AMINE DERIVATIVES

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专利权人:

TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人:

SHINICHI URAYAMA,EIGO MUTOU,ATSUSHI INAGAKI,TAKASHI OKADA,SHIGEHARU SUGISAKI

申请号：

MYPI 20054286

公开号：

MY147822A

申请日:

2005.09.12

申请国别(地区):

MY

年份:

2013

代理人:

摘要：

INDUSTRIAL PROCESS FOR PRODUCING HIGHLY PURE OPTICALLY ACTIVE AMINE DERIVATIVES, WHEREIN FORMATION OF SIDE PRODUCTS ARE CONTROLLED, IS PROVIDED. IN SAID PROCESS, (E)- 2-(1,6,7,8-TETRAHYDRO-2H-INDENO [5,4-B] FURAN-8- YLIDENE)ETHYLAMINE IS SUBJECTED TO ASYMMETRIC REDUCTION REACTION, AND FURTHER THE RESULTING REACTION PRODUCTS ARE CATALYTICALLY REDUCED UNDER A CONDITION OF REACTION TEMPERATURE OF 40°C TO 100°C AND PH 3 TO 9, THEN THE OBTAINED (S)- 2-(1,6,7,8-TETRAHYDRO-2H-INDENO [5,4-B] FURAN-8- YL)ETHYLAMINE IS SUBJECTED TO PROPIONYLATION REACTION, FOLLOWED BY CRYSTALLIZING FROM THE REACTION SOLUTION.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/