DEWDNEY, NOLAN, JAMES,KONDRU, RAMA, K. K,LOE, BRADLEY, E. E,LOU, YAN,MCINTOSH, JOEL,OWENS, TIMOTHY, D. D,SOTH, MICHAEL,蒂莫西‧,‧歐文斯,邁克爾‧索思,諾蘭‧詹姆斯‧德沃丹尼,拉馬‧,‧孔杜,布拉德利‧,‧洛伊,婁岩,喬爾‧麥金托什
申请号：
HK11107060.7
公开号：
HK1152940B
申请日:
2011.07.08
申请国别(地区):
HK
年份:
2014
代理人:
摘要：
This application discloses 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives according to generic Formulae I-IV: wherein, variables R, X, Y1, Y2, Y2, Y3, Y4, n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-IV and at least one carrier, diluent or excipient.
