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CDK8/CDK9 SELECTIVE INHIBITORS AND THEIR USE IN ANTI-METASTATIC AND CHEMOPREVENTIVE METHODS FOR CANCER
专利权人:
SENEX BIOTECHNOLOGY INC.
发明人:
IGOR B RONINSON,DONALD C. PORTER,MARK P. WENTLAND
申请号:
MYPI 2014002269
公开号:
MY165446A
申请日:
2013.02.01
申请国别(地区):
MY
年份:
2018
代理人:
摘要:
THE INVENTION RELATES TO THE COMPOUNDS AND METHODS FOR INHIBITING THE CYCLIN-DEPENDENT KINASE INHIBITOR (CDKI) PATHWAY. MORE PARTICULARLY, THE INVENTION RELATES TO COMPOUNDS AND METHODS FOR INHIBITING THE CDKI PATHWAY FOR STUDIES OF AND INTERVENTION IN SENESCENCE-RELATED AND OTHER CDKI -RELATED DISEASES. THE INVENTION PROVIDES NEW COMPOUNDS HAVING IMPROVED SOLUBILITY AND/OR POTENCY, AND METHODS FOR THEIR USE. IN VARIOUS ASPECTS, THE INVENTION RELATES TO THE TREATMENT OF CANCER. THE INVENTION PROVIDES METHODS FOR CHEMOPREVENTION AND PREVENTION OF TUMOR RECURRENCE OR METASTASIS. THE INVENTION FURTHER PROVIDES DIAGNOSTIC TECHNIQUES FOR TREATMENT FOR CERTAIN CANCER TYPES. THE INVENTION UTILIZES SPECIFIC INHIBITORS OF CDK8/19 AND/OR MEASUREMENT OF CDK8 LEVELS IN A PATIENT. THE MOST SUITABLE DRAWING: FIG 3.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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