METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND SELECTIVE TREATMENT OF CANCER

• 收藏
• 分享

专利权人:

发明人:

Deepak Nijhawan,Ting Han,Nicholas H. Gaskill

申请号：

US15821111

公开号：

US20180140578A1

申请日:

2017.11.22

申请国别(地区):

US

年份:

2018

代理人:

摘要：

In one aspect, provided herein are methods for treating cancer in a subject, comprising: (1) identifying in the subject the presence of a mutation in a splicing factor selected from the group consisting of U2AF1, SF3B1, SRSF2, and ZRSR2 and/or determining in the subject an increased amount of DCAF15 compared to a control, and (2) inhibiting an activity of RBM39 in the subject. In some embodiments, the inhibiting step can include promoting RBM39 degradation, preferably in a DCAF15-dependent manner. Compositions are also provided.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/