Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propionic acid methyl ester benzenesulfonate

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专利权人:

PAION UK LIMITED

发明人:

Yuji Kawakami,Tatsushi Murase,Daisuke Tanaka,Hideyuki Yoshiyama,Shinitsu Kuwabe

申请号：

US15488361

公开号：

US09981941B2

申请日:

2017.04.14

申请国别(地区):

US

年份:

2018

代理人:

摘要：

A process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]-benzodiazepin-4-yl]propionic acid methyl ester benzenesulfonate by oxidation of 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]d-iazepin-3-yl]propionic acid methyl ester in the presence of an oxidation catalyst is provided.

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