OXIDATION REACTION WITH EXCELLENT CONVERSION RATE

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专利权人:

PAION UK LIMITED

发明人:

KAWAKAMI, YUJI,MURASE, TATSUSHI,TANAKA, DAISUKE,YOSHIYAMA, HIDEYUKI,KUWABE, SHINITSU

申请号：

EP14759551

公开号：

EP2966069A4

申请日:

2014.03.03

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

A process for preparing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4,-benzodiazepin-3-yl]propionic acid methyl ester at a high conversion rate with good reproducibility by oxidizing 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester in the presence of an oxidation catalyst is provided by defining the ammonium ion content of 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester.

来源网站：

中国工程科技知识中心

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