Process for preparing 3-[(S)-7-bromo-2-((2-oxopropyl)amino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester

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专利权人:

PAION UK LIMITED

发明人:

Yuji Kawakami,Tatsushi Murase,Daisuke Tanaka,Hideyuki Yoshiyama,Shinitsu Kuwabe

申请号：

US15875948

公开号：

US10414749B2

申请日:

2018.01.19

申请国别(地区):

US

年份:

2019

代理人:

摘要：

A process for preparing 3-[(S)-7-bromo-2-((2-oxo propyl)amino)-5-pyridin-2-yl-3H-1,4,-benzodiazepin-3-yl]propionic acid methyl ester (compound (FK)), at a high conversion rate with good reproducibility by oxidizing 3-[(S)-7-bromo-2-(2-hydroxypropylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3yl]propionic acid methyl ester (compound (EM)), in the presence of an oxidation catalyst is provided by defining the ammonium ion content of the oxidation reaction mixture.

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中国工程科技知识中心

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http://www.ckcest.cn/home/