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CONJUGATION OF PHARMACEUTICALLY ACTIVE AGENTS WITH TRANSTHYRETIN LIGANDS THROUGH ADJUSTABLE LINKERS TO INCREASE SERUM HALF-LIFE
专利权人:
MAMOUN M. ALHAMADSHEH
发明人:
MAMOUN M. ALHAMADSHEH,MIKI S. PARK,WILLIAM K. CHAN,XIAOLING LI,SRAVAN C. PENCHALA,MARK R. MILLER
申请号:
US14804024
公开号:
US20160045609A1
申请日:
2015.07.20
申请国别(地区):
US
年份:
2016
代理人:
摘要:
A delivery system for active agents, and methods of making and using the systems, are provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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