MAMOUN M. ALHAMADSHEH,MIKI S. PARK,WILLIAM K. CHAN,XIAOLING LI,SRAVAN C. PENCHALA,MARK R. MILLER
申请号：
US16436412
公开号：
US20190365912A1
申请日:
2019.06.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The teachings provide methods of delivering active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Delivery systems and methods of making and using the delivery systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject； and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.
