KELLY, Michael G.,KINCAID, John,FANG, Yunfeng,CAO, Yeyu,KAUB, Carl,GOWLUGARI, Sumithra,WANG, Zhan
申请号：
ES07753335
公开号：
ES2569677T3
申请日:
2007.03.16
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A bicycloheteroaryl compound having a formula: ** Formula ** in which B and Y are independently selected from CR2a and CR2aR2b； W and Z are selected from CH； W 'is CR4； L1 is substituted or unsubstituted C1-C5 alkylene； n is 1 or 2； R1 is selected from a substituted or unsubstituted aryl ring or substituted or unsubstituted heteroaryl； each of R2a, R2b, R2 'and R2' 'is independently selected from hydrogen, halo, and substituted or unsubstituted C1-C6 alkyl； or any of R2 'and R2' 'join together to form a cycloalkyl or cycloheteroalkyl ring of 3-7 atoms； R3 is hydrogen or a functional group selected from alkyl, dialkylamino, acyloxy, alkoxy, and -SO2-alkyl； or the group -L1-R3 is selected from ** Formula ** R4 is independently selected from H, alkyl, substituted alkyl, acyl, substituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl, substituted or unsubstituted alkylamino, arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl, substituted or unsubstituted sulfone, substituted or unsubstituted sulfone, substituted sulfanyl, aminosulf substituted or unsubstituted, substituted or unsubstituted arylsulfonyl, sulfuric acid, sulfuric acid ester, substituted or unsubstituted dihydroxyphosphoryl, substituted or unsubstituted aminodihydroxyphosphoryl, azido, carboxy, substituted or unsubstituted carbamoyl, cyanoalkyl substituted or unsubstituted, cycloalkyl replaced or unsubstituted, substituted or unsubstituted dialkylamino, halo, heteroaryloxy, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalkyl, hydroxy, nitro, and thio； and the point link is a single or double link； or a pharmaceutically acceptable salt or solvate thereof； and stereoisomers, isotopic variants and tautomers thereof.Un compuesto bicicloheteroarilo que tiene una fórmula:**Fórmula** en la que B e
