TACHDZHIAN Ketrin (US),ТАЧДЖИАН Кэтрин (US),TAN Syao Tsin (US),ТАН Сяо Цин (US),KARANEVSKI Donald S (US),КАРАНЕВСКИ Дональд С (US),SERVANT Gaj (US),СЕРВАНТ Гай (US),LI Syaodun (US),ЛИ Сяодун (US),CHZH,TACHDZHIAN Ketrin,ТАЧДЖИАН Кэтрин,TAN Syao Tsin,ТАН Сяо Цин,KARANEVSKI Donald S,КАРАНЕВСКИ Дональд С,SERVANT Gaj,СЕРВАНТ Гай,LI Syaodun,ЛИ Сяодун,CHZHAN Fen,ЧЖАН Фэн,CHEN Tsin,ЧЭНЬ Цин,CHZHAN Khun,ЧЖА
申请号：
RU2014109126
公开号：
RU0002617700C2
申请日:
2012.08.10
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a new derivative of quinoline of formula (I)(I)or its salt suitable for internal use, where R1 and R2 represents hydrogen； L represents a C1-C7 alkylene, C3-C6 cycloalkylene or -(CH2)1-3-(C3-C6) cycloalkylene； M represents -NR4-C(O)- or -C(O)-NR4-； when M represents -NR4-C(O)-, R4 represents hydrogen； or alternatively R4 represents a C1-C3 alkilinity linker, where the specified alkilinity linker and from 2 to 5 atoms of L, together with the nitrogen to which they are attached, form a 5-8-membered monocyclic, bicyclic or bridged heterocyclic ring that is optionally substituted and contains one hetero-atom representing a nitrogen atom； and R3 represents a C1-C6 alkyl, a substituted C1-C3 alkyl, a C3-C6 cycloalkyl, a substituted C3-C6 cycloalkyl, a 6-membered heterocyclyl containing one oxygen atom, or a substituted 6-membered heterocyclyl containing one nitrogen atom； when M represents -C(O)-NR4-, R4 represents hydrogen； or alternatively R4 and R3 together with the nitrogen to which they are attached form a 5-6-membered monocyclic heterocyclic ring which contains one nitrogen atom； where in the group indicated as substituted, one substituent is selected from the group consisting of the following substituents: -NH2, a hydroxyl, a C1-6 alkoxy, a C1-6 alkyl, a 6-membered heterocyclyl containing one or two atoms selected from N and O, a C3-4 cycloalkyl, and C(=O)NRaRa, where each Ra independently means hydrogen or a C3-6 cycloalkyl； provided that the compounds of the formula (I) cannot represent compounds mentioned in claim 1. The invention also relates to a composition based on a compound of the formula (I) and methods for enhancing the sweet taste.EFFECT: new quinoline derivatives useful as sweet taste modifiers are obtained.31 cl, 24 tbl, 24 exИзобретение относится к области органической химии, а именно к новому производному хинолина формулы (I) или к его пригодной для употребления внутрь соли, где R1 и R2 представляет с
