< Topic >Large quantity addition of the transmitted accelerator is made possible without decreasing the cohesion power of the adhesive compound, in addition, biological utilization talent of the medicine improves, the percutaneous absorption die formulation which is satisfied also the basic performance which is required at the same time remaining behind and the skin to the skin of the adhesive compound as the percutaneous absorption die formulation such that the being attached which is expressed is improved is offered.SolutionsProviding the adhesion agent layer in the base material, the adhesion agent composition which forms the said adhesion agent layer in the percutaneous absorption die formulation which becomes, the acrylic Acid ester which does not have the carboxyl group inside the numerator and/or polymerization the monomer or monomer blend which consists of methacrylic acid ester, the acrylic adhesive compound which makes the resin which becomes main, the basic medicine, mean particle diameter contains the silica grain, and the polyatomic alcohol fatty acid ester of 5 millimicrons or less, the aforementioned polyatomic alcohol fatty acid ester becomes 15 - 40 mass % being included in proportion, vis-a-vis all mass of the adhesion agent composition, the percutaneous absorption die formulation.< Choice figure > It is not【課題】粘着剤の凝集力を低下させることなく透過促進剤の多量添加を可能にし、また、薬物の生物学的利用能を向上させ、且つ粘着剤の皮膚への残留や皮膚のべたつきを改善するなどの経皮吸収型製剤として求められる基本性能をも満足する経皮吸収型製剤を提供すること。【解決手段】支持体に粘着剤層を設けてなる経皮吸収型製剤において、該粘着剤層を形成する粘着剤組成物が、分子内にカルボキシル基を持たないアクリル酸エステル及び/またはメタクリル酸エステルよりなるモノマー又はモノマー混合物を重合してなる樹脂を主とするアクリル系粘着剤、塩基性薬物、平均粒子径が5μm以下のシリカ粒子、並びに多価アルコール脂肪酸エステルを含有し、前記多価アルコール脂肪酸エステルは粘着剤組成物の全質量に対して15~40質量%の割合で含まれてなる、経皮吸収型製剤。【選択図】 なし
