< Topic >Large quantity addition of the transmitted accelerator is made possible without decreasing the cohesion power of the adhesive compound, in addition, biological utilization talent of the medicine improves, the percutaneous absorption die formulation which is satisfied also the basic performance which is required at the same time remaining behind and the skin to the skin of the adhesive compound as the percutaneous absorption die formulation such that the being attached which is expressed is improved is offered.SolutionsProviding the adhesion agent layer in the base material, the adhesion agent composition which forms the said adhesion agent layer in the percutaneous absorption die formulation which becomes, the acrylic Acid ester which does not have the carboxyl group inside the numerator and/or being the monomer or monomer blend which essentially becomes from methacrylic acid ester, to exceed 0% has the carboxyl group the monomer which on the basis of the number of entire of monomer mols due to when and polymerization those which are included in proportion of 5% or less, the adhesive compound which makes the acrylic adhesive compound which consists of the resin which becomes main, the basic medicine, to contain the silica grain, and the polyatomic alcohol fatty acid ester, as for the aforementioned polyatomic alcohol fatty acid ester adhesion15 - 40 mass % being included in proportion vis-a-vis all mass of the agent composition, it becomes, the percutaneous absorption die formulation.< Choice figure > It is not【課題】粘着剤の凝集力を低下させることなく透過促進剤の多量添加を可能にし、また、薬物の生物学的利用能を向上させ、且つ粘着剤の皮膚への残留や皮膚のべたつきを改善するなどの経皮吸収型製剤として求められる基本性能をも満足する経皮吸収型製剤を提供すること。【解決手段】支持体に粘着剤層を設けてなる経皮吸収型製剤において、該粘着剤層を形成する粘着剤組成物が、分子内にカルボキシル基を持たないアクリル酸エステル及び/またはメタクリル酸エステルより本質的に成るモノマー又はモノマー混合物であって、場合によりカルボキシル基を持つモノマーをモノマーの総モル数に基づいて0%を超え5%以下の割合で含むものを重合してなる樹脂からなるアクリル系粘着剤を主とする粘着剤、塩基性薬物、シリカ粒子、並びに多価アルコール脂肪酸エステルを含有し、前記多価アルコール脂肪酸エステルは粘着剤組成物の全質量に対して15~40質量%の割合で含まれてなる、経皮吸収型製剤。【選択図】 なし
