Amram Mor,Richard M. Epand,Raquel F. Epand,Brigitte Papahadjopoulos-Sternberg
申请号：
US13389008
公开号：
US08951563B2
申请日:
2010.08.05
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed are compositions-of-matter comprising polymer-mediated cochleates, which are formed from a calcium-free mixture of a wide variety of phospholipids that are atypical for forming cochleates. Further disclosed are compositions-of-matter comprising these cochleates which co-encapsulate another bioactive agent. The polymer mediating the formation of these cochleates exhibits a plurality of positively charged amino acid residues and omega-amino-fatty acid moieties, and may further exhibit antimicrobial, anticancerous and drug-potentiating activity. Further disclosed are pharmaceutical compositions and methods using the compositions-of-matter disclosed herein, and processes of preparing same.
