An extended release formulation of a broad spectrum macrolide antibiotic such as mainly Clarithromycin which is comprising of a unique blend of polymer matrix, NaHCO3 (Sodium bicarbonate) and other excepients in a optimized ratio to achieve an extended drug release profile upto 12 hours without any chemical interaction between drug & other excepients. Moreover due to this extended drug release profile of the present Clarithomycin formulation, it is easier to establish the facts on a theoretical basis that our Clarithromycin formulation, using an unique blend of polymer matrix, can be used for the effective management of H, pylori induced infections.