An example of an information processing system includes a stationary type device and a hand-held type device. The stationary type device senses first user information for evaluating QOL of a user while the user is asleep. The hand-held type device senses second user information for evaluating QOL of the user while the user is awake. The information processing system performs an evaluation regarding QOL of the user on the basis of the first user information and the second user information. The first user information and the second user information may be of the same type or different types.