PROBLEM TO BE SOLVED: To provide a new use of a component of fish oil, particularly a new use for promoting health. A composition for reducing trimethylamine N oxide in serum containing a component selected from monounsaturated fatty acids having 20 or more carbon atoms, a salt thereof and an ester thereof as an active ingredient. The composition wherein the active ingredient is derived from fish oil. The composition wherein the fish oil is saury oil. [Selection diagram] None【課題】魚油の成分の新規用途、特に健康増進に関する新規用途の提供。【解決手段】炭素数20以上のモノ不飽和脂肪酸、その塩およびそのエステルから選択される成分を有効成分として含有する、血清中トリメチルアミンNオキシド低減用組成物。有効成分が魚油由来である、前記組成物。魚油がサンマ油である、前記組成物。【選択図】なし