AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO - A.C.R.A.F. - S.p.A.
发明人:
ALISI, Maria Alessandra,CAZZOLLA, Nicola,GAROFALO, Barbara,FURLOTTI, Guido,MAGARO', Gabriele,OMBRATO, Rosella,MANCINI, Francesca
申请号：
ES13703799
公开号：
ES2564033T3
申请日:
2013.02.08
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compounds of 1H-indazol-3-carboxamide having the following general formula (I) ** Formula ** in which Ra and Ra ', the same or different from each other, are a hydrogen atom； a halogen atom； a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl and C1-C6 alkoxy group, optionally substituted by one or more substituents, selected from the group consisting of halogen, hydroxy, -NH2 and C1-C3 alkoxy； a carbocyclic or heterocyclic, aliphatic or aromatic ring, having 3 to 12 members, optionally substituted by one or more substituents, selected from the group consisting of halogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, - NR1R2 , -C (O) OH, -C (O) OR1 and -C (O) NR1R2； Y is a bond, a C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl group, optionally substituted by one or more substituents selected from the group consisting of halogen, hydroxy, -NH2 and C1-C3 alkoxy； Rb is a carbocyclic or heterocyclic, aliphatic or aromatic ring, having 3 to 12 members, substituted with one or more substituents selected from the group consisting of halogen, hydroxy, nitro, cyano, -CF3, C1-C6 alkoxy, benzyloxy, C1-C4 alkyl, C2-C4 alkenyl and C2-C4 alkynyl, -NHSO2CH3, -SO2NH2, -ZC (O) OH, -ZC (O) OR1 and -ZC (O) NR1R2, where Z is a σ bond or (C1-C3) alkyl； R1 and R2 are independently a hydrogen atom, a C1-C4 alkyl group, a C2-C4 alkenyl group, a C2-C4 alkynyl group and a phenyl group； and its addition salts with pharmaceutically acceptable organic and inorganic acids and bases； for the use in the treatment of a disease that originates from uncontrolled activation and / or overexpression of GSK-3β, selected from the group consisting of (i) insulin resistance disorders； (ii) neurodegenerative diseases； (iii) mood disorders； (iv) schizophrenic disorders； (v) cancerous disorders； (vi) inflammation； (vii) substance abuse disorders； and (viii) epilepsies.Compuestos de 1H-indazol-3-carboxamida que presentan la fórmula general (I) siguiente**Fórmula** en la que Ra y Ra', iguales o diferentes entre sí, son un átomo de
