PROBLEM TO BE SOLVED: To provide pharmaceuticals containing a compound having strong effect of modulating α7 nicotinic acetylcholine receptor (α7nAChR) and useful as treatment agent for diseases related to cholinergic in central nervous system (CNS) and/or peripheral nervous system (PNS), diseases related to smooth muscle contraction, endocrine diseases, diseases related to neurodegeneration or the like.SOLUTION: There is provided pharmaceuticals containing a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof. (I), where A is CR1E or N, X-Y-Z is N-CO-NR3AR3B or the like, R1A to R1E and R2A to R2D are each independently an alkyl group or a cycloalkyl group substituted or unsubstituted by H, halogen, cyano, F, an alkoxy group or the like , R3A and R3B represent each independently an alkyl group or a cycloalkyl group substituted or unsubstituted by phenyl, heterocyclic monoaromatic ring cycloalkyl group or the like, and n represents 1 or 2.COPYRIGHT: (C)2015,JPO&INPIT【課題】強いα7ニコチン性アセチルコリン受容体(α7nAChR)の調節作用を有し、中枢神経系(CNS)及び/又は末梢神経系(PNS)のコリン作動性に関する疾患、平滑筋収縮に関する疾患、内分泌疾患、神経変性に関する疾患等の治療薬として有用な化合物からなる医薬の提供。【解決手段】式(I)で表される化合物又はその製薬学的に許容される塩からなる医薬。[AはCR1E又はN;X-Y-ZはN-CO-NR3AR3B等;R1A~R1E及びR2A~R2Dは各々独立にH、ハロゲン、シアノ、F又はアルコキシ基等で置換/未置換のアルキル基或いはシクロアルキル基等、R3A及びR3Bは各々独立に、フェニル、複素単芳香環シクロアルキル基等で置換/未置換のアルキル基、シクロアルキル等を表し、nは、1又は2を表す]【選択図】なし
