Bartlett, Perry F.,Goldshmit, Yona,Boyd, Andrew W.,Turnley, Ann M.,Galea, Mary P.
申请号：
AU2005282217
公开号：
AU2005282217B2
申请日:
2005.09.08
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to a method of treating disorders of the nervous system and more particularly disorders associated with a gliotic response and/or an inflammatory response within the central nervous system and to therapeutic agents useful for same. More particularly, the present invention involves a method of preventing or reducing the amount of Eph receptor-mediated gliosis and/or glial scarring and/or inflammation and/or Eph receptor-mediated inhibition of axonal growth which occurs during and/or after disease or injury to the nervous system. The present invention also facilitates the identification of therapeutic agents which modulate Eph receptor-mediated signaling. The method and therapeutic agents of the present invention are useful for treating a range of nervous system diseases, conditions and injuries including, inter alia, paralysis induced by physiological-, pathological- or trauma-induced injury to the brain or spinal cord.
