WANG, LI-HSIEN,DORE, ANTHONY T.,STEVENS, SEAN,MURPHY, ANDREW J.
申请号：
PL12795905
公开号：
PL2663575T3
申请日:
2012.10.29
申请国别(地区):
PL
年份:
2015
代理人:
摘要：
Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R± locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.
