WANG LI HSIEN,DORE JR. ANTHONY T.,STEVENS SEAN,MURPHY ANDREW J.
申请号：
IN3920CHN2014
公开号：
IN3920CHN2014A
申请日:
2014.05.23
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
Mice that comprise a replacement of endogenous mouse IL 6 and/or IL 6 receptor genes are described and methods for making and using the mice. Mice comprising a replacement at an endogenous IL 6Ra locus of mouse ectodomain encoding sequence with human ectodomain encoding sequence is provided. Mice comprising a human IL 6 gene under control of mouse IL 6 regulatory elements is also provided including mice that have a replacement of mouse IL 6 encoding sequence with human IL 6 encoding sequence at an endogenous mouse IL 6 locus.
